Seongho Kim Selected Research

Hydroxymethyl and Formyl Transferases

1/2021	Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
1/2020	Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.

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Seongho Kim Research Topics

Disease

33	Neoplasms (Cancer) 03/2022 - 01/2014
10	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2014
7	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 10/2016
6	Neoplasm Metastasis (Metastasis) 01/2022 - 10/2016
5	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 12/2017
4	Multiple Myeloma 01/2020 - 09/2015
3	Brain Neoplasms (Brain Tumor) 01/2022 - 12/2017
3	Squamous Cell Carcinoma of Head and Neck 10/2021 - 01/2019
3	Triple Negative Breast Neoplasms 01/2021 - 01/2017
2	Infections 04/2022 - 09/2015
2	Ovarian Neoplasms (Ovarian Cancer) 03/2022 - 01/2022
2	Pneumonia (Pneumonitis) 10/2021 - 02/2019
2	Liver Diseases (Liver Disease) 05/2021 - 08/2011
2	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021 - 01/2019
2	Melanoma (Melanoma, Malignant) 01/2021 - 01/2014
2	Hemorrhage 03/2020 - 08/2015
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 03/2019
2	Fibrosis (Cirrhosis) 03/2019 - 08/2011
2	Fever (Fevers) 01/2017 - 09/2015
2	Pleural Effusion (Pleural Effusions) 01/2017 - 01/2016
2	Pain (Aches) 10/2016 - 04/2014
1	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2022
1	Morbid Obesity 01/2022
1	T-Cell Lymphoma (Lymphoma, T Cell) 01/2022
1	Hodgkin Disease (Hodgkin's Disease) 01/2022
1	Esophagitis 01/2022
1	Dermatitis 01/2022
1	Ovarian Epithelial Carcinoma 01/2022
1	Acidosis 10/2021
1	Cranial Nerve Diseases (Cranial Nerve Disorders) 10/2021
1	COVID-19 08/2021
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 08/2021

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 01/2022 - 12/2017
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2016
4	pyrimidineIBA 01/2022 - 01/2019
4	EnzymesIBA 01/2021 - 10/2019
4	Hormones (Hormone)IBA 06/2020 - 01/2018
3	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 12/2018
3	purineIBA 01/2022 - 01/2020
3	Immune Checkpoint InhibitorsIBA 10/2021 - 10/2017
3	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2020
3	Estrogen ReceptorsIBA 06/2020 - 01/2018
3	LipidsIBA 03/2019 - 01/2013
2	VaccinesIBA 04/2022 - 08/2021
2	Folic Acid AntagonistsIBA 01/2022 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2018
2	NucleotidesIBA 01/2022 - 01/2021
2	LigandsIBA 10/2021 - 01/2019
2	Tissue Inhibitor of Metalloproteinase-1IBA 10/2021 - 01/2020
2	RibonucleotidesIBA 01/2021 - 01/2020
2	CarbonIBA 01/2021 - 01/2020
2	Hydroxymethyl and Formyl TransferasesIBA 01/2021 - 01/2020
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 01/2020
2	CateninsIBA 01/2021 - 01/2014
2	glycinamide ribonucleotideIBA 01/2021 - 01/2020
2	CollagenIBA 11/2020 - 03/2019
2	Phenobarbital (Luminal)FDA Link 06/2020 - 01/2018
2	Progesterone FDA LinkGeneric 06/2020 - 01/2018
2	Estrogens (Estrogen)FDA Link 06/2020 - 01/2018
2	MicroRNAs (MicroRNA)IBA 06/2020 - 01/2018
2	Protein Isoforms (Isoforms)IBA 06/2020 - 01/2018
2	RNA (Ribonucleic Acid)IBA 01/2020 - 03/2019
2	Cetuximab (Erbitux)FDA Link 01/2020 - 01/2019
2	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)IBA 01/2020 - 10/2019
2	plerixafor FDA Link 01/2020 - 11/2016
2	enzalutamideIBA 01/2020 - 12/2018
2	Fatty Acids (Saturated Fatty Acids)IBA 03/2019 - 01/2013
2	adavosertibIBA 01/2018 - 12/2017
1	COVID-19 VaccinesIBA 04/2022
1	Eicosapentaenoic AcidIBA 03/2022
1	Metformin (Glucophage)FDA LinkGeneric 03/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	GadoliniumIBA 01/2022
1	Insulin-Like PeptidesIBA 01/2022
1	ets-Domain Protein Elk-1IBA 01/2022
1	ceritinibIBA 01/2022
1	Brentuximab VedotinIBA 01/2022
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2022
1	ChromatinIBA 01/2022
1	Caspase 8 (Caspase-8)IBA 10/2021
1	pembrolizumabIBA 10/2021
1	Carbonic Anhydrase IXIBA 10/2021
1	Metalloproteases (Metalloproteinases)IBA 10/2021
1	Small Interfering RNA (siRNA)IBA 10/2021
1	Cell Surface ReceptorsIBA 10/2021
1	Bile Acids and Salts (Bile Acids)IBA 05/2021
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 03/2021
1	PlatinumIBA 01/2021

Therapy/Procedure

14	Therapeutics 03/2022 - 10/2016
4	Radiotherapy 01/2022 - 03/2021
4	Hematopoietic Stem Cell Transplantation 01/2022 - 09/2015
4	Stem Cell Transplantation 08/2021 - 09/2015
3	Drug Therapy (Chemotherapy) 10/2021 - 09/2015
2	Chemoradiotherapy 03/2021 - 11/2020
2	Neck Dissection (Radical Neck Dissection) 03/2020 - 08/2015
2	Castration 01/2020 - 12/2018
1	Segmental Mastectomy (Lumpectomy) 01/2022
1	Induction Chemotherapy 08/2021
1	Photochemotherapy (Photodynamic Therapy) 03/2021